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Examination

Biohacking is a broad term that refers to a DIY approach to optimizing one's biology and overall well-being. Essentially, it is about making small, incremental changes to your body, brain, or lifestyle to improve performance, health, or longevity. Below is a Guide Table to help navigate each section and enhance appreciation from a scientific perspective!



Recent talks held at two leading universities, titled “Knowledge in the Age of AI” and “Innovation for Impact” fueled a deeper interest in understanding GPT technology - its inner workings, applications, and potential. The discussion explored AI innovations - from how they are currently applied, where they are most needed, and how they are being developed. Here are the general notes on this.

Knowledge in the Age of AI
Seminar talk with Informatics Departmental 
In recent years, large language models have greatly impacted research and products across various fields, from healthcare to soda flavor development. While early excitement may have been overstated, generative AI is undeniably a transformative technology with a profound impact, though its full extent is still unclear.

Q. What role do knowledge infrastructures, graphs and metadata repositories play in this new world?
In this world of rapidly advancing technology, interconnected systems, and growing data volumes, knowledge infrastructure, metadata repositories, and knowledge graphs play a big role in enabling data management and decision making. 

A knowledge graph for example is a structured representation of knowledge that captures relationships between different concepts or entities. They represent entities (like people, places, products, etc.) as nodes, and relationships between them as edges. Knowledge graphs use semantic technologies to organize data and uncover deeper insights through pattern recognition and relationship mapping. Knowledge infrastructures on the other hand provide the foundation systems for knowledge creation, sharing and utilization across industries. 

Knowledge graphs can integrate clinical, genomic, and experimental data to help identify patterns, relationships, and insights that may not be apparent in isolated datasets. Metadata repositories be utilized to manage data from various sources. This includes brain imaging, genomics, patient records, and clinical trials. 

Q. How will knowledge representations fit into a world transformed by LLMs?
The deployment of large language models (LLMs) has changed the way we approach and think about knowledge representation. Traditionally, knowledge representation (KR) has focused on formalizing information in ways that machines can process and reason about, such as through ontologies, semantic networks, logic-based systems or knowledge graphs. With the rise of LLMs, we are seeing a shift in how knowledge is represented, organized, and interacted with.

To process language, the brain relies on neural networks, just like how a machine learning model uses artificial neural networks (ANNs) to understand and generate language. Both systems aim to recognize patterns in language (words, phrases, sounds) and predict what comes next based on learned experiences or data.

As people construct sentences, the brain analyzes what words or phrases are most likely to follow given the structure of the sentence and previous experiences with language. For example - The brain predicts how to complete a thought or sentence. In a conversation, if someone says, "I love to play soccer because it’s," the brain might predict they will say "fun" or "exciting" based on the context of the conversation.

Problem: Handwritten Digit Classification
Goal: Build a model to classify handwritten digits (0–9) from pixel data.

— Trueblogposts (@trueblogposts) June 5, 2025
Innovation for Impact
Symposiums with BioScience Futures
Medical innovations, cloud infrastructure, and artificial intelligence (AI) are reshaping healthcare at a fast pace. The technologies work in connection together to drive advancements in medical research, patient care, and healthcare management. 

Q. What role does machine learning play in Life Sciences and structure prediction?
Machine learning is being applied in areas such as protein folding, RNA secondary structure prediction, and drug design. One of the most notable successes of ML in biological structure prediction is AlphaFold, developed by DeepMInd. The goal is to predict the 3D structure of a protein based on its amino acid sequence. Predicting protein structure has been a major challenge in biology because the number of possible configurations of a protein is astronomically large.

AlphaFold uses deep learning techniques to model the physical and chemical properties that govern protein folding. By training on known protein structures, AlphaFold can predict highly accurate 3D structures for proteins that have not been experimentally solved. This has led to breakthroughs in understanding diseases, drug design and biological pathways! In 2021, AlphaFold was able to predict the structure of all proteins in the human genome with great accuracy.

Q. Let's discuss the impact of integrating Cloud and AI in Healthcare.
Cloud infrastructure includes physical and virtual resources (servers, storage, networking, etc.) that are hosted on remote servers (data centers) and accessed over the internet (the cloud). This includes the storage, processing, and management of vast amounts of data like patient records, diagnostic images, and treatment histories.

The integration of Cloud computing and AI in healthcare is currently in effect as Telemedicine and Remote Consultations. Cloud-based healthcare platforms enabling remote consultations, reducing the need for patients to travel long distances to see specialists. Cloud computing enables healthcare professionals to collaborate across geographic boundaries, sharing knowledge, research, and medical data seamlessly. Ai-powered tools are currently assisting doctors during these remote consultations.

“Mere models, understanding systems”- Chatbots are not actually understanding the content they generate, but simply following patterns learned during training.

— Trueblogposts (@trueblogposts) March 20, 2025

Additional Topic Research 
Face-to-face and digital articles
Neurotech is a rapidly growing field. It focuses on developing technologies that interact with the nervous system, aiming to enhance or restore brain function, monitor brain activity, and address neurological disorders. 

Q. Examples of bridging the gap between Mind and Medicine?
Psychosomatic medicine examines how psychological factors impact physical health, with conditions like chronic pain, gastrointestinal issues, and heart disease often worsened by anxiety or depression. Doctors in this field address both mental and physical health. Psychoneuroimmunology in contrast, studies the connection between the brain, immune system, and mental health, showing how stress can affect immune function and contribute to illness. This has led to treatments like stress reduction techniques and therapy. 

Natural Language Processing (NLP), wearable sensors, big data and analytics, and Deep Learning are key technologies that will support these applications. NLP can be applied for analyzing text-based data like patient records, therapy notes, or journal entries to understand psychological states, to Deep learning for processing complex data, such as imaging (e.g. brain scans) or time-series data (e.g. heart rate).

Q. What's the discourse on advanced tools and techniques?
Brain-Computer Interfaces (BCIs) lead into the broader field of Neurotechnology, which includes neurostimulation, neuroprosthetics, neurodiagnostics, and monitoring. 

These technologies can help reduce physical strain in various ways. For example, BCIs may minimize the need for repetitive motions, potentially preventing issues like carpal tunnel syndrome or repetitive stress injuries. For workers with disabilities, neuroprosthetics offer the chance to regain lost functionality, making workplaces more accessible.

For individuals dealing with mental health conditions, whether short-term or long-term, Deep Brain Stimulation (DBS) or neurostimulation could offer therapeutic benefits, enhancing emotional well-being and promoting a better work-life balance, potentially reducing burnout. Additionally, neuropharmaceuticals like nootropics could help with improving memory, learning, and decision-making skills, ultimately boosting their performance.
 
So.. Does it makes sense?
Many machine learning algorithms are inspired by the way the brain works. For example, deep learning models are based on the brain's layered structure for solving problems and processing information hierarchically. The field of neuroscience has also played a key role in driving the development of more interpretable AI. How? Techniques like attention mechanisms and neural symbolic networks in the past have now helped us understand how AI models make decision. This all links back to our understanding of how the brain makes its own decisions!



Resources
(Article) Empowering people to unlock AI’s full potential
Nearly all companies invest in AI, but only 1 percent feel they have reached full maturity. The firm's research shows that the main obstacle to scaling is not the employees who are ready—but the leaders, who are not moving quickly enough.

(Article) The Interplay of Neuroscience & Artificial Intelligence: A Synergistic Evolution
In the ever-evolving landscape of scientific research, the intersection of neuroscience and artificial intelligence (AI) highlights the strength of interdisciplinary collaboration. 

(Online) Neuroscience - Bulletin
Discover the latest research in Neuroscience, including insights on how brain activity can enhance workplace culture, the application of neuroscience in leadership training, and the connection between organizational trust and business performance. 


Last updated: 16/03/2025



Cartoon fantasy
Suborbital flight

This is a rapidly evolving industry, and the next frontier holds exciting possibilities. We are currently entering a new phase of human space exploration, where private individuals - those not affiliated with government space agencies - are able to travel into space for leisure, research, and science. This post will go on to discuss this further.

Suborbital Flights 

This is the most immediate and accessible form of space tourism, offering brief experiences of space without fully entering orbit. Companies like Blue Origin and Virgin Galactic have already begun offering suborbital flights, allowing passengers to experience a brief period of weightlessness and view the curvature of the Earth. As the technology becomes more refined, suborbital flights will become more routine and affordable. This may eventually lead to enhanced spaceports and infrastructure.

Companies must anticipate to stay ahead of the curve. Technological advancements in areas such as space debris management, propulsion systems, and more broadly, environmental sustainability can affect opportunities. Firms must allocate resources effectively for research and development while balancing the costs of innovation and scaling!

Orbital Space Travel 
With this form of tourism, people will move into orbit. This would enable them to experience space for longer periods and gaining more immersive experiences, such as weightlessness and the view of Earth from space. SpaceX has made significant strides with its Crew Dragon spacecraft, which has already taken astronauts to the International Space Station (ISS). Companies are working on plans for private missions, including paying tourists. SpaceX’s Starship is poised to change the game and the idea of offering extended trips of a few days or more in space will become more feasible. 

Effective supply chain management and strategic supplier relationships will be crucial to ensure timely delivery of components and equipment, as well as to avoid delays in the production and operation of space vehicles. Companies need to invest time and money in developing supply chain resilience, considering strategies like vertical integration or establishing partnerships to secure access to critical components.

“Our two greatest problems are gravity and paperwork. We can lick gravity, but sometimes the paperwork is overwhelming”. - Wernher von Braun

— Trueblogposts (@trueblogposts) March 5, 2025

Space Hotels
As space tourism expands, infrastructure like space hotels will become essential to support longer stays in orbit or around Earth. Space hotels indeed represent a significant step toward the commercialization of space travel - allowing people to stay in low Earth orbit or beyond. People can enjoy views of Earth, weightlessness, and unique space experiences. While it is not fully operational just yet, various companies are working on plans to make this a reality in the coming few years. Orbital hotels, space pods, and modules require remarkable concept and design-work.

To achieve strategic fit, companies need to be clear about their value proposition - whether it is providing luxury, unique experiences, or affordability. Segmenting and targeting the market is essential to ensure that the company can maintain a competitive edge. Due to shifts in technology, consumer demand, and competition, business models must also adapt quickly.

Deep Space and Lunar 
Travel past Earth’s orbit, including to the Moon, is the next step in space exploration and tourism, offering truly unique experiences in deep space. SpaceX and Blue Origin have plans to develop spacecraft capable of interplanetary travel. While prices are decreasing, space tourism will remain expensive in the near future, limiting it to a select group of people. As the number of space tourists grows, managing space traffic and regulating space missions will become critical. Currently, there is no infrastructure for public lunar or Mars trips, but plans are in development!

The industry will require highly specialized skills, ranging from aerospace engineers and astronauts to customer service professionals trained to handle high-stress, high-tech environments. HR departments will need to focus on recruiting talent with deep technical expertise and specialized knowledge in space exploration, aerospace technology, and relevant safety protocols. Recruitment programs will likely include simulations of space environments, emergency response drills, and customer handling in extreme conditions.

"To be the first to enter the cosmos, to engage, single-handed, in an unprecedented duel with nature—could one dream of anything more?" - Yuri Gagarin

— Trueblogposts (@trueblogposts) March 5, 2025

Mars Colonization 
The final frontier, involving the establishment of permanent human settlements, past the Moon, to Mars! This requires significant technological advancements and infrastructure, making it the ultimate step in humanity’s expansion beyond Earth. In the long term, the intersection of Mars colonization and space tourism could fundamentally reshape our relationship with both space and our planet. Developing the technology for Mars colonization demands innovations in spacecraft, propulsion systems, life-support systems, and radiation protection. Furthermore, Mars colonization necessitates long-term solutions for water, oxygen, and food production. Frequent transportation, from a to b to c, would also be essential for the planet to become both accessible and reliable.

Companies must implement robust risk management strategies and safety protocols to meet evolving regulatory requirements, mitigate liability risks, and build public trust. They must ensure compliance with national and international regulations related to space travel. Lobbying efforts may also be necessary to establish clear policies. 

So... Number of steps for mankind?
With advanced in technology and the increasing involvement of private companies, space tourism is on the cusp of becoming a more accessible and popular industry, poetically opening up new frontiers for travel and exploration, while also offering unique opportunities for scientific research and economic growth. Business management ensures that all facets of space tourism - from finances and regulations to customer experience and technology - work in harmony, allowing the industry to thrive and reach its potential.



Resources
(Site) Humans in Space - Commercial Space - NASA
The webpage focuses on the role of commercial spaceflight in supporting human space exploration. It provides an overview of NASA's Commercial Crew and Commercial Lunar Payload Services programs, emphasizing the importance of the private sector's involvement in space exploration.

(Article) What's Happening in Space in 2025?
The article from the National Space Centre discusses major space missions planned for 2025. It highlights a number of lunar exploration efforts, such as NASA's Blue Ghost lander and Blue Origin's Moon missions.

(Article) NASA Space Tech’s Favorite Place to Travel in 2025: The Moon!
The article sheds light on the Artemis program, which aims to return humans to the Moon, and the cutting-edge technologies that will be used to support lunar exploration and future human settlements on the Moon.



Last updated: 06/03/2025
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